1. Introduction 2. Background of Dental Caries 2.1. Definition and Overview 2.2. Prevalence in Early Childhood 2.3. Traditional Causative Factors 3. Oral Microbiome: General Aspects 3.1. Composition and Importance 3.2. Variation Across Age Groups 3.3. Methods of Analysis 4. Relationship Between Oral Microbiome and Dental Caries 4.1. Microbial Pathogenesis in Caries 4.2. Specific Bacterial Influence 4.3. Dysbiosis and Caries Development 5. Recent Research Findings 5.1. Studies in Early Childhood 5.2. Microbiome's Impact on Caries Formation 5.3. Limitations in Current Research 6. Preventive Strategies and Treatments 6.1. Oral Hygiene Practices 6.2. Probiotics and Prebiotics 6.3. Fluoride Use and Alternatives 7. Implications for Public Health 7.1. Early Intervention Protocols 7.2. Education and Awareness 7.3. Policy Recommendations 8. Conclusion and Future Directions 8.1. Summary of Key Findings 8.2. Suggestions for Future Studies 8.3. Long-term Impact on Childhood Health
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