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1. Introduction 2. Microglia: An Overview 2.1 Defining Microglia 2.2 Microglia in the Central Nervous System 2.3 Activation States of Microglia 2.4 Methods to Study Microglia 3. Neuroplasticity in the Brain 3.1 Concepts of Neuroplasticity 3.2 Mechanisms Driving Neuroplasticity 3.3 Microglia's Role in Synaptic Remodeling 3.4 Case Studies and Experiments 4. Microglia and Neurodegenerative Diseases 4.1 Alzheimer's Disease 4.2 Parkinson's Disease 4.3 Amyotrophic Lateral Sclerosis 4.4 Multiple Sclerosis 5. Microglia-Mediated Inflammatory Responses 5.1 Cytokine Release Mechanisms 5.2 Impact on Neuronal Survival 5.3 Inflammation in Disease Context 6. Therapeutic Implications 6.1 Targeting Microglia for Treatment 6.2 Anti-inflammatory Strategies 6.3 Recent Advances in Clinical Trials 7. Current Challenges and Future Directions 7.1 Limitations of Current Research 7.2 Technological Advances Required 7.3 Future Prospects in Microglia Research 8. Conclusion
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