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1. Introduction 2. Microglia: An Overview 2.1 Origin and Development of Microglia 2.2 Microglial Activation States 2.3 Microglia in Brain Homeostasis 3. Synaptic Plasticity Fundamentals 3.1 Definition and Mechanisms 3.2 Types of Synaptic Plasticity 3.3 Factors Influencing Synaptic Plasticity 4. Microglia and Synaptic Interaction 4.1 Role in Synaptic Remodeling 4.2 Microglial Signaling Pathways 4.3 Microglia in Synaptic Pruning 5. Microglia in Cognitive Function 5.1 Cognitive Roles of Microglia 5.2 Microglial Impact on Learning 5.3 Memory and Microglial Activity 6. Pathological Microglial Activity 6.1 Microglia in Neurodegenerative Diseases 6.2 Cytokines and Neuroinflammation 6.3 Impact on Synaptic Dysfunction 7. Therapeutic Potential of Modulating Microglia 7.1 Strategies for Microglial Regulation 7.2 Microglia as Therapeutic Targets 7.3 Current Research and Future Directions 8. Conclusion and Future Perspectives 8.1 Summary of Key Findings 8.2 Implications for Cognitive Restoration 8.3 Areas for Future Research
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