1. Introduction 1.1 Background of Green Chemistry 1.2 Importance in Pharmaceuticals 1.3 Research Objectives 2. History of Green Chemistry 2.1 Origins and Development 2.2 Key Figures and Contributions 2.3 Milestones in Green Chemistry 3. Principles of Green Chemistry 3.1 Twelve Principles Overview 3.2 Application in Pharmaceuticals 3.3 Benefits and Challenges 4. Sustainable Pharmaceutical Manufacturing 4.1 Definition and Scope 4.2 Key Sustainability Metrics 4.3 Role of Green Chemistry 5. Case Studies in Pharmaceutical Industry 5.1 Successful Implementations 5.2 Lessons Learned 5.3 Barriers and Solutions 6. Green Chemistry Techniques and Methods 6.1 Alternative Solvents 6.2 Biocatalysis in Manufacturing 6.3 Energy-Efficient Processes 7. Economic and Environmental Benefits 7.1 Cost Reduction Approaches 7.2 Environmental Impact Analysis 7.3 Long-term Sustainability Goals 8. Future Directions and Innovations 8.1 Emerging Technologies 8.2 Policy and Regulatory Frameworks 8.3 Research and Development Priorities
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