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1. Introduction 1.1 Background and Motivation 1.2 Objectives of the Study 1.3 Structure of the Paper 2. Overview of Epigenetic Modifications 2.1 Definition and Types 2.2 Key Epigenetic Mechanisms 2.3 Role in Gene Regulation 3. Cancer Drug Resistance 3.1 Definition and Importance 3.2 Conventional Mechanisms of Resistance 3.3 Challenges in Overcoming Resistance 4. Epigenetic Modifications in Cancer 4.1 Common Epigenetic Changes in Cancer 4.2 Impact on Tumor Initiation 4.3 Influence on Cancer Progression 5. Relationship Between Epigenetics and Drug Resistance 5.1 How Epigenetics Affects Drug Response 5.2 Examples of Resistance Due to Epigenetics 5.3 Potential Predictive Markers 6. Current Therapeutic Strategies 6.1 Epigenetic Therapy Approaches 6.2 Combination Treatments with Epigenetic Drugs 6.3 Limitations and Challenges 7. Emerging Research and Future Directions 7.1 Innovative Technologies in Epigenetics 7.2 Potential New Targets for Therapy 7.3 Future Research Directions 8. Conclusion 8.1 Summary of Key Findings 8.2 Implications for Cancer Treatment 8.3 Final Thoughts and Recommendations
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