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1. Introduction 2. Metabolites and Cancer Biology 2.1 Definition and Classification of Metabolites 2.2 Metabolic Pathways in Cancer Cells 2.3 Role of Metabolites in Tumor Microenvironment 3. Mechanisms of Cancer Progression 3.1 Metabolic Reprogramming in Cancer 3.2 Impact of Metabolites on Cell Proliferation 3.3 Metabolites and Angiogenesis 4. Metabolites and Therapeutic Resistance 4.1 Resistance Mechanisms in Cancer Treatment 4.2 Influence of Metabolites on Drug Efficacy 4.3 Metabolite-mediated Genetic and Epigenetic Changes 5. Metabolomics in Cancer Research 5.1 Techniques in Metabolomics Studies 5.2 Challenges in Metabolomics Data Analysis 5.3 Applications in Biomarker Discovery 6. Metabolite-targeted Cancer Therapies 6.1 Current Therapeutic Approaches 6.2 Development of Metabolite Inhibitors 6.3 Impact of Combination Therapies 7. Case Studies and Clinical Trials 7.1 Case Study: Breast Cancer Metabolites 7.2 Analysis of Clinical Trial Data 7.3 Future Prospects in Metabolite-based Treatments 8. Conclusion 9. Future Directions and Research Opportunities 9.1 Emerging Trends in Metabolite Research 9.2 Potential for Innovative Therapies 9.3 Interdisciplinary Approaches in Cancer Treatment
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