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1. Introduction 1.1 Background of Cancer Metabolism 1.2 Importance of Epigenetic Modifications 1.3 Objectives of the Study 2. Overview of Epigenetic Mechanisms 2.1 DNA Methylation 2.2 Histone Modifications 2.3 Non-coding RNAs 3. Cancer Metabolism and Its Adaptations 3.1 Metabolic Reprogramming in Cancer 3.2 Role of Metabolites in Cancer Progression 3.3 Connections to Epigenetic Regulation 4. Epigenetic Influence on Cancer Metabolism 4.1 Modulation of Enzymes by Epigenetics 4.2 Interaction with Metabolic Pathways 4.3 Epigenetic Reprogramming in Tumor Cells 5. Mechanisms of Therapeutic Resistance 5.1 Drug Resistance in Cancer Treatment 5.2 Contribution of Metabolic Alterations 5.3 Emerging Resistance Through Epigenetics 6. Therapeutic Strategies Targeting Epigenetics 6.1 Current Epigenetic Therapies 6.2 Development of Epigenetic Drugs 6.3 Combining Epigenetic and Metabolic Inhibitors 7. Case Studies and Experimental Approaches 7.1 Case Study: Specific Cancer Types 7.2 Experimental Models Used 7.3 Outcomes and Insights Gained 8. Future Directions and Conclusions 8.1 Challenges in Research and Application 8.2 Potential for Personalized Medicine 8.3 Summary of Key Findings
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