1. Introduction 2. Overview of Metabolic Diseases 2.1 Definition and Classification 2.2 Prevalence and Impact 2.3 Current Treatment Approaches 3. Basics of Epigenetic Modifications 3.1 DNA Methylation 3.2 Histone Modification 3.3 Non-coding RNAs 4. Epigenetic Modifications in Metabolic Diseases 4.1 Obesity and Insulin Resistance 4.2 Type 2 Diabetes Mellitus 4.3 Cardiovascular Diseases 5. Mechanisms Linking Epigenetics and Metabolism 5.1 Gene Expression Regulation 5.2 Cellular Energy Homeostasis 5.3 Inflammation and Immune Response 6. Diagnostic Biomarkers 6.1 Epigenetic Biomarkers in Metabolic Diseases 6.2 Techniques for Detection 6.3 Clinical Applications 7. Therapeutic Strategies Targeting Epigenetics 7.1 Pharmacological Agents 7.2 Lifestyle and Dietary Interventions 7.3 Gene Editing Technologies 8. Future Perspectives and Research Directions 8.1 Challenges and Limitations 8.2 Interdisciplinary Approaches 8.3 Potential for Personalized Medicine
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