1. Introduction 2. Microbiome and Human Health 2.1 Definition and Composition 2.2 Microbiome Diversity in Humans 2.3 Microbiome's Impact on Homeostasis 3. Overview of Metabolites 3.1 Types of Metabolites 3.2 Metabolite Synthesis Pathways 3.3 Characterization Techniques for Metabolites 4. Interactions Between Metabolites and Immune System 4.1 Mechanisms of Modulation 4.2 Key Metabolites Involved 4.3 Role in Autoimmune Diseases 5. Immunomodulatory Properties of Specific Metabolites 5.1 Short-Chain Fatty Acids 5.2 Polyphenols and Their Effects 5.3 Tryptophan Metabolites in Immunity 6. Clinical Implications 6.1 Microbiome Alterations and Disease 6.2 Therapeutic Potential of Metabolites 6.3 Limitations and Challenges in Therapy 7. Recent Advances in Research 7.1 Novel Methodologies in Study 7.2 Key Findings in Recent Studies 7.3 Emerging Trends in Microbiome Science 8. Conclusion and Future Directions 8.1 Summary of Key Insights 8.2 Proposed Areas for Further Research 8.3 Potential Impact on Healthcare Strategies
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